Author

M. S. Dillingham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 8 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:chromatin & epigenetic regulation· 5 Research Focus:cell signaling & trafficking· 4 Organism:bacteria (other)· 3 Approach:biophysical modeling· 3 Assay:DNA methylation· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

F. Moreno-Herrero· 4 shared C. Aicart-Ramos· 3 shared O. J. Wilkinson· 3 shared D. B. Wigley· 2 shared F. Sobott· 2 shared I. Collinson· 2 shared S. De Braganca· 2 shared W. J. Allen· 2 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersBiochemistry

F. Moreno-Herrero

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Author profile →

9 papers

Recent·Most cited

DNA binding and bridging by human CtIP in the healthy and diseased states

S. Lokanathan Balaji, S. De Braganca, F. Balaguer-Perez, S. Northall, O. J. Wilkinson, C. Aicart-Ramos, F. Sobott, N. Seetaloo, F. Moreno-Herrero, M. S. Dillingham

This study investigates the DNA binding and bridging activities of CtIP in healthy and diseased states, identifying a C-terminal DNA-binding domain and showing that tetramerization is required for DNA bridging.

bioRxiv · Dec 14, 2023 · PreprintBiochemistry

Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub

M. Wilkinson, O. J. Wilkinson, C. Feyerherm, E. E. Fletcher, D. B. Wigley, M. S. Dillingham

The paper presents structural and biochemical analysis of two phage proteins that inhibit or co-opt the bacterial RecBCD complex to evade host immunity.

bioRxiv · Sep 12, 2022Biochemistry

Towards a molecular mechanism underlying mitochondrial protein import through the TOM and TIM23 complexes

H. C. Ford, W. J. Allen, G. C. Pereira, X. Liu, M. S. Dillingham, I. Collinson

This study uses a split NanoLuc luciferase assay to analyze the kinetics of mitochondrial protein import through the TIM23MOTOR complex, identifying rate-limiting steps and their dependence on precursor properties.

bioRxiv · Aug 30, 2021Biochemistry

DNA mismatch and damage detection using a FRET-based assay for monitoring the loading of multiple MutS sliding clamps

V. Kunetsky, O. Storozhuk, G. Brouwer, C. Laffeber, M. S. Dillingham, J. Lebbink, P. Friedhoff

The paper develops a FRET-based assay using MutS to detect DNA mismatches and damage by monitoring ATP-dependent loading of multiple MutS sliding clamps.

bioRxiv · Jul 23, 2021 · PreprintBiochemistry

Analysis of the PcrA-RNA polymerase complex reveals a helicase interaction motif and a role for PcrA/UvrD helicase in the suppression of R-loops.

I. Urrutia, J. Ault, F. Sobott, N. Savery, M. S. Dillingham

This study identifies a helicase interaction motif in the PcrA-RNAP complex and shows PcrA's role in suppressing R-loops by resolving transcription-replication conflicts.

bioRxiv · Mar 15, 2021Biochemistry

Cytidine triphosphate promotes efficient ParB-dependent DNA condensation by facilitating one-dimensional spreading from parS

F. d. A. Balaguer, C. Aicart-Ramos, G. L. Fisher, S. de Braganca, C. L. Pastrana, M. S. Dillingham, F. Moreno-Herrero

The paper investigates how CTP binding enhances ParB-dependent DNA condensation through one-dimensional spreading from parS sites.

bioRxiv · Feb 11, 2021Biophysics

Refined measurement of SecA-driven protein transport reveals indirect coupling to ATP turnover

W. J. Allen, D. W. Watkins, M. S. Dillingham, I. Collinson

This study uses a split luciferase assay to measure SecA-driven protein transport in bacteria, revealing stepwise transport coupled to ATP hydrolysis without a distinct initiation event.

bioRxiv · May 8, 2020 · PreprintBiochemistry

Bulk and single-molecule analysis of a novel DNA2-like helicase-nuclease reveals a single-stranded DNA looping motor

O. Wilkinson, C. Carrasco, C. Aicart-Ramos, F. Moreno-Herrero, M. S. Dillingham

This study characterizes a bacterial DNA2-like helicase-nuclease, Bad, revealing its ssDNA looping motor activity and cryptic DNA unwinding properties.

bioRxiv · Nov 21, 2019 · PreprintBiochemistry

Human CtIP forms a tetrameric dumbbell-shaped particle which binds and bridges complex DNA end structures for double-strand break repair

O. J. Wilkinson, A. Martin-Gonzalez, H. J. Kang, S. J. Northall, D. B. Wigley, F. Moreno-Herrero, M. S. Dillingham

This study shows human CtIP forms a tetramer that binds and bridges DNA ends, facilitating resection for double-strand break repair.

bioRxiv · Sep 5, 2018Biochemistry