Evolutionary rise of a synaptic mechanism for creating and diversifying key reinforcement signals
Natalia Rodríguez-Sosa, Lupita Rios, You‐Hsin Lin, Volodymyr Rybalchenko, Yash Sharma, Alaa Hajeissa, Ian Chambers, Nien-Shao Wang, Raghav Rajesh, Vishal Narla, Steven J. Shabel
The paper shows that GABA co-release in the lateral habenula produces TD-like computations linked to decision-making, and that this mechanism evolved across vertebrates.
bioRxiv · Aug 28, 2026 · PreprintNeuroscience