Ian Chambers

The paper identifies a non-catalytic repressor function of TET1 and an activating role of macroH2A.2 in bivalent chromatin during neuroectoderm differentiation.

This study investigates NANOG's rheological properties, showing it forms self-limiting micelles that modulate DNA dynamics and may regulate gene expression through gel-like environments.

This study shows OTX2 controls chromatin accessibility to promote somatic differentiation over germline fate in embryonic cells.

This study identifies a direct interaction between NANOG and RNA Polymerase II that regulates transcription and ESC self-renewal.

This study shows that TET protein deficiency in mouse ESCs leads to impaired somatic differentiation and accelerated germline entry.

This study shows that NANOG induces germline entry by repressing Otx2, while ESRRB cannot do so due to insufficient Otx2 repression, revealing a mechanism in PGC specification.

This study shows that RESF1 loss reduces ESC self-renewal and PGCLC differentiation efficiency in mice, but not NANOG-driven self-renewal without LIF.

This study shows that competence to epithelialise and differentiate in pluripotent cells is regulated by Tcf15, linking these processes through integrin alpha3 upregulation.

The paper identifies two distinct pluripotency states in mouse embryonic stem cells (mESCs) based on G2M phase enrichment, showing naive and formative states marked by Esrrb expression levels.

The paper identifies functional enhancers in human embryonic stem cells using a combination of chromatin immunoprecipitation and a massively parallel reporter assay, revealing novel enhancer classes and activity patterns.

The paper quantifies Sox2 and Oct4 synergistic binding to Sox/Oct motifs, showing Sox2 levels drive Fgf4 expression, influencing cell fate decisions in mouse embryos.