Persistent glycolysis defines the foreign body response to polymeric implants.
Christian N. Rempe, Neal I. Callaghan, Lauren Fong-Hollohan, Sarah Nersesian, Zachary S.C.S. Froom, Kyle Medd, Ibrahim Ahmed, Tobias K. Karakach, Jeanette E. Boudreau, Michael Bezuhly, Locke Davenport Huyer
This study identifies glycolysis, specifically GLUT1-dependent metabolism, as a key metabolic pathway in peri-implant macrophages and multinucleated giant cells during the foreign body response to polymeric implants.
bioRxiv · Feb 4, 2025 · PreprintImmunology