Locke Davenport Huyer

This study shows age and sex affect fibrosis and immune response in a mouse model of implant-induced chronic inflammation through changes in T cell and macrophage phenotypes.

This study shows that γδ17 T cells influence fibrosis by altering ECM composition and vascularity through interactions with stromal cells.

This study shows that tissue injury accelerates tumor growth and reduces response to immunotherapy in mice, but biomaterials that enhance wound healing can improve outcomes and ICB response.

This study develops degradable polyester biomaterials via ROCOP, showing that monomer selection significantly affects degradation behavior and material properties.

The paper identifies Treg clonal expansion and immunosuppressive functions in fibrosis induced by synthetic implants, showing their role in modulating stromal cell behavior.

This paper develops itaconate polymer microparticles for intracellular delivery of itaconate to regulate macrophage inflammation, showing reduced cytotoxicity and metabolic changes.

This study identifies glycolysis, specifically GLUT1-dependent metabolism, as a key metabolic pathway in peri-implant macrophages and multinucleated giant cells during the foreign body response to polymeric implants.