The sodium-glucose cotransporter 2 inhibitor tofogliflozin induces vasodilation by activating Kv channels, the SERCA pump, and the sGC/cGMP pathway
Wenwen Zhuang, Minju Park, Jeong JunSu, Hye Ryung Kim, YeEun Jang, Mi Seon Seo, Jin Ryeol An, Hongzoo Park, Won-Kyo Jung, Il-Whan Choi, Won Sun Park
This study shows tofogliflozin induces vasodilation in rabbit arteries by activating Kv channels, the SERCA pump, and the sGC/cGMP pathway, independent of endothelium or PKA.
European Journal of Pharmacology · Apr 6, 2025Peer-reviewedPharmacology & Toxicology