Author

Indraniel Das

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 3 Genetics· 2 Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:statistical model· 7 Research Focus:GWAS / association mapping· 5 Assay:whole-genome sequencing· 5 Research Focus:variant calling· 2 Research Focus:variant effect prediction· 2 Assay:whole-exome sequencing· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Ira M. HalliD· 6 shared Haley AbeliD· 5 shared Markku LaaksoiD· 5 shared Nathan O. StitzieliD· 5 shared Aarno V. PalotieiD· 4 shared Adam E. LockeiD· 4 shared David E. LarsoniD· 4 shared Erica P. YoungiD· 4 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersGenetic & Genomic Medicine

Ira M. HallORCID

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Author profile →

7 papers

Recent·Most cited

Genealogy based trait association with LOCATER boosts power at loci with allelic heterogeneity

Xinxin Wang, Ryan Christ, Erica P. Young, Chul Joo Kang, Indraniel Das, Edward A. Belter, Markku Laakso, Louis J. M. Aslett, David Steinsaltz, Nathan O. Stitziel, Ira M. Hall

The paper introduces LOCATER, a genealogy-based method that improves trait association power by leveraging haplotype diversity and allelic heterogeneity, identifying novel associations and recovering known loci in a Finnish cohort.

Genome Research · May 1, 2026Peer-reviewedGenetic & Genomic Medicine

Genome-wide association study of 1,391 plasma metabolites in 6,136 Finnish men identifies 303 novel signals and provides biological insights into human diseases

Xianyong Yin, Lap Sum Chan, Debraj Bose, Anne Jackson, Peter VandeHaar, Adam E. Locke, Christian Fuchsberger, Heather M. Stringham, Ryan Welch, Ketian Yu, Lilian Fernandes Silva, Susan K. Service, Daiwei Zhang, Emily C. Hector, Erica P. Young, , Michael Boehnke

This study identifies 303 novel genetic signals associated with plasma metabolites in Finnish men, revealing biological insights into disease mechanisms.

Nature Communications · Mar 28, 2022Peer-reviewedGenetic & Genomic Medicine

Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences

Liron Ganel, Lei Chen, Ryan Christ, Jagadish Vangipurapu, Erica P. Young, Indraniel Das, Krishna Kanchi, David E. Larson, Allison Regier, Haley Abel, Chul Joo Kang, Alexandra J. Scott, Aki Samuli Havulinna, Charleston W. K. Chiang, Susan K. Service, , Ira M. Hall

Human Genomics · Jun 7, 2021Peer-reviewedGenetic & Genomic Medicine

Association of Structural Variation with Cardiometabolic Traits in Finns

Lei Chen, Haley Abel, Indraniel Das, David E. Larson, Liron Ganel, Krishna Kanchi, Allison Regier, Erica P. Young, Chul Joo Kang, Alexandra J. Scott, Colby Chiang, Xinxin Wang, Shuangjia Lu, Ryan Christ, Susan K. Service, , Ira M. Hall

This study identifies 31 genome-wide significant associations between structural variations and cardiometabolic traits in Finns, including two novel loci with strong phenotypic effects.

The American Journal of Human Genetics · Apr 1, 2021Peer-reviewedGenetics

svtools: population-scale analysis of structural variation

David E. Larson, Haley Abel, Colby Chiang, Abhijit Badve, Indraniel Das, James M. Eldred, Ryan M. Layer, Ira M. Hall

svtools enables population-scale structural variation analysis by providing a fast, scalable toolkit and cloud pipeline for high-quality SV mapping across thousands of human genomes.

Bioinformatics · Jun 17, 2019Peer-reviewedBioinformatics

Mapping and characterization of structural variation in 17,795 deeply sequenced human genomes

Haley Abel, David E. Larson, Colby Chiang, Indraniel Das, Krishna Kanchi, Ryan M. Layer, Benjamin M. Neale, William J. Salerno, Catherine Reeves, Steven G. Buyske, Tara Cox Matise, Donna Marie Muzny, Michael C. Zody, Eric S. Lander, Susan K. Dutcher, , Ira M. Hall

The paper maps and characterizes structural variants in 17,795 human genomes, revealing their frequency, impact, and relationship to gene dosage and regulatory elements.

bioRxiv · Dec 31, 2018 · PreprintGenomics

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

Andrea Ganna, F. Kyle Satterstrom, Seyedeh Maryam Zekavat, Indraniel Das, Mitja Kurki, Claire Churchhouse, Jessica Alföldi, Alicia R. Martin, Aki Samuli Havulinna, Andrea Byrnes, Wesley Kurt Thompson, Philip Rising Nielsen, Konrad J. Karczewski, Elmo Saarentaus, Manuel A. Rivas, , Benjamin M. Neale

The paper investigates the impact of rare protein truncating variants on 13 quantitative traits and 10 diseases using whole-exome sequencing data from 100,296 individuals, finding increased risk for several disorders and associations with other phenotypes.

The American Journal of Human Genetics · May 31, 2018Peer-reviewedGenetics