Ryan Christ

Genealogy based trait association with LOCATER boosts power at loci with allelic heterogeneity

The paper introduces LOCATER, a genealogy-based method that improves trait association power by leveraging haplotype diversity and allelic heterogeneity, identifying novel associations and recovering known loci in a Finnish cohort.

Clade Distillation for Genome-wide Association Studies

The paper introduces LOCATER, a method to test genealogical trees for association with traits, showing improved power over traditional methods in detecting allelic heterogeneity.

Variant Set Distillation

The paper introduces vsdistill, a method for improving power in genomics by distilling variant sets, and demonstrates its effectiveness through simulations and UK Biobank analysis.

Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences

Association of Structural Variation with Cardiometabolic Traits in Finns

This study identifies 31 genome-wide significant associations between structural variations and cardiometabolic traits in Finns, including two novel loci with strong phenotypic effects.