Author

Isaac N. Joshua

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:ATAC-seq· 2 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:GWAS / association mapping· 1 Approach:matrix factorization· 1

Frequent Co-Authors

Agnieszka D’Antonio‐ChronowskaiD· 2 shared Kelly A. FrazeriD· 2 shared Matteo D’AntonioiD· 2 shared Timothy D. ArthuriD· 2 shared André Ducati LuchessiiD· 1 shared Angelo D. Arias· 1 shared Athanasia D. PanopoulosiD· 1 shared Benjamin A. Henson· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Agnieszka D’Antonio‐ChronowskaORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

IFNγ activates an immune-like regulatory network in the cardiac vascular endothelium

Timothy D. Arthur, Isaac N. Joshua, Jennifer P. Nguyen, Agnieszka D’Antonio‐Chronowska, Matteo D’Antonio, Kelly A. Frazer

This study investigates how IFNγ affects cardiac vascular endothelium by analyzing RNA-seq and ATAC-seq data from iPSC-derived cells, revealing immune-like regulatory changes and GWAS variant overlaps.

Journal of Molecular and Cellular Cardiology Plus · Feb 19, 2025Peer-reviewedBioinformatics

Analysis of regulatory network modules in hundreds of human stem cell lines reveals complex epigenetic and genetic factors contribute to pluripotency state differences between subpopulations

Timothy D. Arthur, Jennifer Nguyen, Agnieszka D’Antonio‐Chronowska, Hiroko Matsui, Nayara Sousa da Silva, Isaac N. Joshua, Lana Ribeiro Aguiar, Angelo D. Arias, Paola Benaglio, W. Travis Berggren, Juan Carlos Izpisúa Belmonte, Victor Borja, Megan Cook, Christopher DeBoever, Kenneth E. Diffenderfer, , Kelly A. Frazer

The paper identifies regulatory network modules in human stem cells, showing epigenetic and genetic factors influence pluripotency state differences.

Nature Communications · Feb 23, 2024Peer-reviewedGenomics