SigSpace: an LLM-based agent for drug responsesignature interpretation
Rohit Khurana, Ishita Mangla, Giovanni Palla, Siddhant Sanghi, Daniele Merico
SigSpace uses an LLM to interpret drug response signatures from cancer cell lines, generating summaries that outperform random baselines in matching to drug identity or mechanism of action.
bioRxiv · Dec 5, 2025 · PreprintBioinformatics