Derivation and theoretical validation of fractional quasi-steady state approximation (fQSSA) for target-mediated drug disposition models with memory effects
Jong Hyuk Byun, Issac Park, Hwi-Yeol Yun, Jae Kyoung Kim
This paper derives and validates a fractional quasi-steady-state approximation for target-mediated drug disposition models with memory effects, showing improved model performance in adults but not infants.
bioRxiv · Apr 29, 2026 · PreprintPharmacology & Toxicology