Hwi‐yeol Yun

This paper derives and validates a fractional quasi-steady-state approximation for target-mediated drug disposition models with memory effects, showing improved model performance in adults but not infants.

This paper derives an exact formula for the competitive qTMDD model, improving computational speed and enabling accurate pharmacological parameter estimation in real-world clinical data.

This paper introduces a hybrid AI framework for drug development that links clinical questions to pharmacokinetic simulations and decision support using PICO specifications and machine learning.

This paper evaluates a novel pTMDD model for drug disposition using clinical data, showing improved accuracy and computational efficiency compared to existing models.