Ndc80 complex, a conserved coupler for kinetochore-microtubule motility, is a sliding molecular clutch
Vladimir M. Demidov, Ivan V. Gonchar, Suvranta K. Tripathy, Атауллаханов Фазоил Иноятович, Ekaterina L. Grishchuk
The paper shows Ndc80 complexes exhibit direction-dependent catch- and slip-bond behavior, modulating sliding friction to enable kinetochore-microtubule coupling.
Science Advances · Sep 3, 2025Peer-reviewedBiophysics