Functional annotation of breast cancer risk loci implicates perturbation of FILIP1L expression in mammary fibroblasts in influencing breast cancer risk.
Alisa Zvereva, Harriet Kemp, Andrea Gillespie, Katarzyna Tomczyk, Shirleny Romualdo Cardoso, Selin Sevgi, Kate Mackie, Vita Fedele, John Alexander, Iain Goulding, Jenny Gomm, J Louise Jones, Joseph S. Baxter, Stephen J. Pettitt, Christopher J. Lord, , Nichola Johnson
The paper identifies a breast cancer risk locus by analyzing functional variants and target genes in mammary fibroblasts, showing their non-autonomous impact on breast cancer risk.
medRxiv · Apr 10, 2026 · PreprintGenetic & Genomic Medicine