Non-synonymous to synonymous substitutions suggest that orthologs tend to keep their functions, while paralogs are a source of functional novelty
J. M. Escorcia-Rodriguez, M. Esposito, J. A. Freyre-Gonzalez, G. Moreno-Hagelsieb
The paper compares dN/dS ratios of orthologs and paralogs to assess functional divergence, finding orthologs more functionally stable than paralogs.
bioRxiv · Jun 22, 2022Evolutionary Biology