BiochemistrybioRxiv
Melanoma-derived DNA polymerase theta variants exhibit altered DNA polymerase activity
C. Thomas, L. Avalos-Irving, J. Victorino…·J. B. Towle-Weicksel
The paper identifies POLQ gene mutations in melanoma tumors and shows they reduce DNA polymerase activity and accuracy, potentially contributing to cancer progression.
DOI 10.1021/acs.biochem.3c00670