Pharmacological activation of constitutive androstane receptor induces female-specific modulation of hepatic metabolism
M. Huillet, F. Lasserre, M.-P. Gratacap, B. Engelmann, J. Bruse, A. Polizzi, T. Fougeray, C. M. P. Martin, C. Rives, A. Fougerat, C. Naylies, Y. Lippi, G. Garcia, E. Rousseau-Bacquie, C. Canlet, , S. Ellero-Simatos
This study shows that pharmacological activation of CAR leads to sex-specific changes in hepatic metabolism and drug-induced liver injury in mice.
bioRxiv · Apr 17, 2023 · PreprintPharmacology & Toxicology