The RNA-dependent interactions of phosphatidylinositol 4,5-bisphosphate with intrinsically disordered proteins contribute to nuclear compartmentalization.
M. Sztacho, J. Cervenka, B. Salovska, L. Antiga, P. Hoboth, P. Hozak
This study identifies RNA-dependent PIP2-associated proteins in human cells and shows their role in nuclear compartmentalization through phase separation.
bioRxiv · Mar 19, 2024 · PreprintCell Biology