Distinct genetic pathways define pre-leukemic and compensatory clonal hematopoiesis in Shwachman-Diamond syndrome
A. L. Kennedy, K. C. Myers, J. Bowman, C. J. Gibson, N. D. Camarda, E. M. Furutani, G. M. Muscato, R. H. Klein, K. Ballotti, S. Liu, C. E. Harris, A. Galvin, M. Malsch, D. Dale, J. M. Gansner, , R. C. Lindsley
The paper identifies distinct genetic pathways in Shwachman-Diamond syndrome that lead to pre-leukemic and compensatory clonal hematopoiesis through EIF6 and TP53 mutations.
bioRxiv · Jun 4, 2020 · PreprintCancer Biology