Author

J. E. Longbotham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

D. Fujimori· 1 shared D. Galonic Fujmori· 1 shared M. J. S. Kelly· 1 shared N. Petronikolou· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 2 mutual co-author links

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1 shared paperBiochemistry

D. Fujimori

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2 papers

Recent·Most cited

Recognition of histone H3 methylation states by the PHD1 domain of histone demethylase KDM5A

J. E. Longbotham, M. J. S. Kelly, D. Galonic Fujmori

This study determines the solution structure of PHD1 domain of KDM5A bound to H3 and reveals its conformational changes and differential interactions with methylated H3K4 peptides.

bioRxiv · Dec 18, 2020Biochemistry

Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A

N. Petronikolou, J. E. Longbotham, D. Fujimori

This study identifies H3 tail residues critical for KDM5A substrate recognition and shows that distal epitopes modulate demethylation activity.

bioRxiv · Nov 25, 2019Biochemistry