Leishmania infection-derived extracellular vesicles drive transcription of genes involved in M2 polarization.
L. Emerson, A. Gioseffi, H. Barker, A. E. Sheppe, J. K. Morrill, M. J. Edelmann, P. E. Kima
This study shows that Leishmania-derived extracellular vesicles (LiEVs) drive M2 macrophage gene transcription, while Salmonella EVs induce M1 polarization, with distinct spatial distributions in infected tissues.
bioRxiv · May 16, 2022Microbiology