J. L. McLellan

Translation inhibition efficacy does not determine the Plasmodium berghei liver stage antiplasmodial efficacy of protein synthesis inhibitors

This study shows that the effectiveness of translation inhibitors against Plasmodium berghei liver stages is not determined by their translation inhibition efficacy, as DDD107498, a weak inhibitor, had strong antimalarial effects.

Single-cell quantitative bioimaging of P. berghei liver stage translation.

The paper develops an assay to visualize and quantify translation in P. berghei liver stages, identifying a compound as a direct translation inhibitor.