Exploring the effect of mechanical anisotropy of protein structures in the unfoldase mechanism of AAA+ molecular machines
R. A. Varikoti, H. Y. Y. Fonseka, M. S. Kelly, A. Javidi, M. Damre, S. Mullen, J. L. Nugent, C. M. Gonzales, G. Stan, R. I. Dima
This study investigates how mechanical anisotropy in protein structures influences the unfolding mechanisms of AAA+ molecular machines like spastin and ClpY.
bioRxiv · Apr 6, 2022Biophysics