Ancient MAPK ERK7 is regulated by an unusual inhibitory scaffold required for Toxoplasma apical complex biogenesis
P. S. Back, W. J. O'Shaughnessy, A. S. Moon, P. S. Dewangan, J. L. Wohlschlegel, J. Sha, P. Bradley, M. L. Reese
The paper identifies AC9 as an essential scaffold for ERK7 regulation during apical complex biogenesis in Toxoplasma gondii, revealing a novel inhibitory mechanism for an ancient MAPK.
Proceedings of the National Academy of Sciences · May 14, 2020Peer-reviewedMicrobiology