Feeding desensitizes A1 adenosine receptors in adipose through FOXO1-mediated transcriptional regulation
M. E. Granade, S. R. Hargett, M. C. Lemke, M. A. Luse, I. Bochkis, J. Linden, T. E. Harris
This study shows that feeding reduces A1R expression in adipose tissue via FOXO1-mediated transcription, impairing insulin suppression of lipolysis and glucose tolerance.
bioRxiv · Mar 4, 2022Physiology