Design Principles for Inflammasome Inhibition by Pyrin-Only-Proteins
Z. Mazanek, S. Wu, G. Belotte, J. J. Zhou, C. M. Stallings, A. Garg, J. Lueck, J. Sohn
This study identifies how pyrin-only-proteins inhibit inflammasomes by targeting different filament assembly steps, revealing their target redundancy and inhibition mechanisms.
bioRxiv · Aug 2, 2022Biochemistry