Circulating immune cell phenotype dynamics reflect the strength of tumor-immune cell interactions in patients during immunotherapy
J. I. Griffiths, P. Wallet, L. T. Pflieger, D. Stenehjem, X. Liu, P. A. Cosgrove, N. A. Leggett, J. McQuerry, G. Shrestha, M. Rossetti, G. Sunga, P. J. Moos, F. R. Adler, J. T. Chang, S. Sharma, A. H. Bild
The paper shows that immune cell dynamics in peripheral blood reflect tumor-immune interactions during immunotherapy, with responder patients showing increased cytotoxic differentiation and interferon signaling.
Proceedings of the National Academy of Sciences · Jun 22, 2020Peer-reviewedCancer Biology