J. T. Chang

Functional Diversity of Memory CD8 T Cells is Spatiotemporally Imprinted

The paper investigates how spatial location influences the functional diversity of memory CD8 T cells by analyzing their transcriptomes in the small intestine.

Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of Th17 immunity

This study identifies intestinal regulatory T cells producing IL-27 to specifically regulate Th17 immunity in the gut, revealing a novel mechanism for tissue-specific immune control.

Cancer cells communicate with macrophages to prevent T cell activation during development of cell cycle therapy resistance

The paper shows cancer cells in resistant tumors promote immune-suppressive macrophages, reducing T-cell activation, and suggests balancing cell cycle inhibition with immune activation for better therapy.

LncRNA Malat1 represses Th17 effector program by maintaining a critical bivalent super-enhancer and promotes intestinal inflammation

This study shows that lncRNA Malat1 restricts Th17 cell IL-17A production by regulating a bivalent super-enhancer, thereby controlling intestinal inflammation resolution.

RORγt serine 182 tightly regulates T cell heterogeneity to maintain mucosal homeostasis and restrict tissue inflammation

This study shows that RORγt serine 182 regulates T cell heterogeneity in the intestine, maintaining homeostasis and limiting inflammation.

Convergent evolution of resistance pathways during early stage breast cancer treatment with combination cell cycle (CDK) and endocrine inhibitors

This study examines how breast cancer tumors evolve during early stage treatment with combination CDK and endocrine inhibitors, finding convergent resistance pathways and increased subclonal diversity with combination therapy.

Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population

This study identifies a terminally differentiated effector memory CD8 T cell population with unique molecular and functional properties that challenge classical definitions of effector memory cells.

Circulating immune cell phenotype dynamics reflect the strength of tumor-immune cell interactions in patients during immunotherapy

The paper shows that immune cell dynamics in peripheral blood reflect tumor-immune interactions during immunotherapy, with responder patients showing increased cytotoxic differentiation and interferon signaling.

A 'one-two punch' therapy strategy to target chemoresistance in estrogen receptor positive breast cancer

This study identifies a sequential therapy strategy using HDAC inhibitors to reverse chemotherapy-induced resistance in ER+ breast cancer by targeting cancer stem cell-like traits.

Functional delineation of tissue-resident CD8 T cell heterogeneity during infection and cancer

This study identifies distinct CD8+ T cell subsets in non-lymphoid tissues during infection and cancer, revealing their functional roles and regulatory mechanisms.

Chemical Impacts of the Microbiome Across Scales Reveal Novel Conjugated Bile Acids

The paper identifies novel conjugated bile acids produced by the microbiome in mice and humans using mass spectrometry and a murine 3D model.