Purifying selection and adaptive evolution proximate to the zoonosis of SARS-CoV-1 and SARS-CoV-2
J. P. Townsend, S. Gaughran, H. B. Hassler, J. N. Fisk, M. Nagib, Y. Wu, Y. Wang, Z. Wang, A. P. Galvani, A. Dornburg
This study analyzes selection pressures in SARS-CoV-1 and SARS-CoV-2 genomes near zoonosis, finding strong purifying selection and limited positive selection, except for NSP12 and ORF7a.
bioRxiv · Aug 7, 2023 · PreprintEvolutionary Biology