Z. Wang

TriStageHLA improves epitope prioritization by integrating peptide screening, binding prediction, and immunogenicity assessment with high accuracy and efficiency.

This study identifies NF-κB-driven chromatin remodeling as a mechanism for drug-induced dedifferentiation in cancer, revealing its role in promoting drug-tolerant persister states.

This study shows that artificial light at night changes plant morphology, reproductive timing, and capacity in Elsholtzia densa, with mixed effects on fitness.

The paper identifies IGFBP3 as a secreted protein that spatially coordinates IGF signaling to promote neonatal cardiac regeneration.

This paper introduces a stretchable microelectrode array that integrates into the developing brain, enabling long-term, stable neural activity tracking without disrupting development.

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

This study shows that miRNA-132-3p/WT1/TGF-beta1 axis regulates the differentiation of THP-1 leukemia cells into macrophages.

This paper introduces Meta-rLLS-VSIM, a super-resolution microscopy technique that achieves near-isotropic resolution with reduced training time and data requirements.

This study identifies BEST4 as a tumor suppressor in colorectal cancer that interacts with Hes4 to inhibit EMT and metastasis.

The paper identifies galectin-9 and AG-specific antibodies that inhibit Mtb growth by targeting arabinogalactan, offering a new immunotherapeutic strategy for TB.

This study shows that two ALS-causing SOD1 mutations form similar amyloid fibrils that promote ferroptosis in neuronal cells.

This study uses single-cell transcriptomics to identify B cell developmental dysfunction in Kawasaki Disease, showing repression of immune processes and altered gene expression in HSPCs and B cells before treatment.

This study combines imaging mass cytometry and single-cell RNA sequencing to analyze the spatial and temporal dynamics of cell interactions and phenotypes in atherosclerotic plaques.

The paper shows that nucleotide depletion and DNA replication stress drive cell fate transitions in hematopoietic systems by activating lineage-specific maturation genes.

This study evaluates hybrid immunity against the Omicron variant JN.1 11 months after breakthrough infection, showing heterogeneous responses and increased neutralization following reinfection.

This paper combines machine learning and PBPK modeling to predict small molecule pharmacokinetics in humans without experimental data, achieving higher accuracy than traditional methods.

This study identifies GLP-1(32-36) as a therapeutic agent that rescues diabetic ischemic lower limbs by enhancing glycolysis and EPC function via GLP-1R-dependent mechanisms.

This study shows chronic nicotine exposure in rabbits increases heart rate, lowers alternans threshold, and reduces sympathetic responses, likely due to hypo-innervation and diminished β-adrenergic responsiveness.

This study investigates how adding straw and microbes accelerates hydrochar aging by identifying key bacterial guilds involved in nutrient cycling.

This study shows ZNF397 loss leads to TET2-driven epigenetic changes, lineage plasticity, and resistance to AR-targeted therapies in AR-dependent cancers, with TET2 inhibitors reversing resistance.

This study identifies a phosphorylation code in 14-3-3 binding motifs that stimulates induced cardiomyocyte formation by disrupting Hdac4 condensates.

The paper uses single-cell RNA sequencing to map zebrafish liver cell types and interactions, identifying macrophage subtypes and their role in nonalcoholic fatty liver disease.

This paper designs and synthesizes a fluorogenic green probe to detect HPSE-1 activity, showing a 278-fold fluorescence turn-on response in the presence of recombinant human HPSE-1.

This study compares chromatin remodeling in colorectal cancer patient-derived models and identifies transcription factors driving differences in growth and drug response.

This study develops a model using M1 macrophage-related genes to predict immunotherapy response and prognosis in advanced NSCLC patients.

The paper investigates how plants and nitrogen fertilizer influence microbial hitchhiking, finding that their synergy affects soil microbiome composition and function depending on nitrogen levels.

This study identifies heparan sulfate as a key regulator of TRAIL-induced apoptosis, showing that HS enhances TRAIL's apoptotic activity by promoting oligomerization and DR5 internalization.

The paper identifies CXCR3-expressing CD8+ T cells as a driver of lung pathology during influenza infection without affecting viral clearance.

This paper introduces a 'live drug' called A-RAWs that uses sunlight to treat systemic bacterial infections by capturing bacteria and killing them with photodynamic therapy upon reaching the skin.