Author
J. P. K. Doye
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Biology Disciplines
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2018-2021 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 14 mutual co-author links3 papers
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Symmetry and simplicity spontaneously emerge from the algorithmic nature of evolution
I. Johnston, K. Dingle, S. F. Greenbury, C. Q. Camargo, J. P. K. Doye, S. E. Ahnert, A. A. Louis
The paper shows that symmetry and simplicity in biological systems arise from algorithmic biases in evolution, not just natural selection, by testing predictions on protein complexes, RNA structures, and gene networks.
bioRxiv · Jul 28, 2021Evolutionary Biology
Substrate conformational dynamics drive structure-specific recognition of gapped DNA by DNA polymerase
T. D. Craggs, M. Sustarsic, A. Plochowietz, M. Mosayebi, H. Kaju, A. Cuthbert, J. Hohlbein, L. Domicevica, P. C. Biggin, J. P. K. Doye, A. N. Kapanidis
This paper investigates how DNA polymerase I recognizes gapped DNA structures through conformational dynamics, revealing a bent DNA structure and using single-molecule FRET and simulations to support the findings.
bioRxiv · Feb 10, 2018Biophysics