A. N. Kapanidis

The paper introduces Gap-Seq, a single-molecule imaging method that links DNA sequence to protein-DNA interaction kinetics by analyzing transient DNA binding to gapped substrates.

The paper investigates RNAP redistribution and increased gene dosage in E. coli with reduced rrn operons, showing RNAP clusters form near remaining rrn operons and growth defects are minimized.

This study uses super-resolution microscopy to analyze influenza virus pleomorphism, revealing stochastic assembly and RNP localization in long filaments.

This study uses single-molecule fluorescence microscopy to show that bacterial RNA polymerase-promoter open complex formation follows a branched pathway with varying stability.

The paper investigates the molecular mechanism of a bacterial flagellar motor switch, revealing its tight regulation, flexibility, and ultrasensitivity through experimental and mathematical analysis.

This paper introduces a rapid, sensitive method for virus detection using Ca2+-mediated virus-DNA interactions, achieving one-minute detection of influenza in clinical samples.

This study analyzes real-time dynamics of influenza virus RNA promoters during replication, revealing differences in initiation mechanisms between vRNA and cRNA promoters.

This paper investigates how DNA polymerase I recognizes gapped DNA structures through conformational dynamics, revealing a bent DNA structure and using single-molecule FRET and simulations to support the findings.

The paper investigates how RNA polymerase pausing controls transcriptional pathways in bacteria, showing that paused RNA synthesis directs RNAP to productive or abortive pathways.