Opto-controlled C9orf72 poly-PR forms anisotropic condensates causative of TDP-43 pathology in the nucleus
R. E. Hodgson, J. Rayment, W.-P. Huang, A. S. Avila, T. A. Shelkovnikova
This study uses optogenetics to model C9orf72 poly-PR condensation in cells, revealing anisotropic nuclear condensates that cause TDP-43 pathology without stress response activation.
bioRxiv · Mar 5, 2024Cell Biology