Transcriptional overlap links DNA hypomethylation with DNA hypermethylation at adjacent promoters in cancer
J. S. Fain, A. Loriot, A. Diacofotaki, A. Van Tongelen, C. De Smet
The paper shows that DNA hypomethylation in tumors can lead to hypermethylation of adjacent promoters through overlapping transcription, linking two opposite epigenetic changes in cancer.
bioRxiv · May 21, 2021Cancer Biology