Cyclic di-AMP traps proton-coupled K+ transporters of the KUP family in an inward-occluded conformation
M. F. Fuss, J.-P. Wieferig, R. A. Corey, Y. Hellmich, I. Tascon, J. S. Sousa, P. J. Stansfeld, J. Vonck, I. Hänelt
This study shows how c-di-AMP binding inhibits KimA by trapping it in an inward-occluded conformation through interactions between transmembrane and cytosolic domains.
bioRxiv · Jan 9, 2023 · PreprintBiophysics