Author

J. S. Weiss

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Biochemistry· 1

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Approach:deep learning· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Assay:structural biology· 1

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F. Zhou· 1 shared W. Li· 1 shared

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2020-2020 · peak 1/yr

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1 shared paperBiochemistry

F. Zhou

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1 paper

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BiochemistrybioRxivPreprintJun 29, 2020

Structural basis for the HMGCR interaction with UBIAD1 mutants causing Schnyder corneal dystrophy

F. Zhou, J. S. Weiss, W. Li

This study uses computational modeling to show that UBIAD1 mutations in Schnyder corneal dystrophy disrupt GGPP binding to HMGCR, increasing structural flexibility and promoting their interaction.

DOI 10.1101/2020.06.29.177683

humanstructural biology

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