Antibody Complementarity Determining Region Design Using High-Capacity Machine Learning
G. Liu, H. Zeng, J. Mueller, B. Carter, Z. Wang, J. Schilz, G. Horny, M. E. Birnbaum, S. Ewert, D. K. Gifford
This paper introduces a machine learning method to design human IgG antibodies with superior target affinity and specificity, using high-throughput data without requiring target structural information.
bioRxiv · Sep 3, 2019Immunology