Cell fate determination by Lamarckian molecule-inheritance and chance
F. J. Bruggeman, J. Schouten, D. H. de Groot, R. Planque
The paper develops a theory to explain cellular heterogeneity by considering stochastic ancestral events in isogenic cell populations, showing that copy-number noise is unavoidable due to cell division stochasticity.
bioRxiv · Apr 24, 2019 · PreprintBiophysics