Inflammation as a Silent Partner in Opioid Addiction: A Regulatory Logic Model
J. Tory Toole, Matthew C. Morris, Cole A. Lyman, Garry L. Spink, Gordon Broderick
The paper constructs a regulatory network model of 44 immune and neurotransmission mediators to show that inflammation is linked to chronic pain, depression, and opioid addiction through increased NF-kB and inflammatory signaling proteins.
bioRxiv · Apr 26, 2022 · PreprintSystems Biology