Effects of alcohol consumption and tobacco smoking on the composition of the ensemble of drug metabolizing enzymes and transporters in human liver
K. A. Gaither, D. K. Singh, G. Yue, J. Trudeau, K. Ponraj, N. Y. Davydova, P. Lazarus, D. Davydov, B. Prasad
This study investigates how alcohol consumption and smoking affect drug-metabolizing enzymes and transporters in human liver microsomes, identifying significant changes in enzyme abundance and proposing an alcohol exposure index.
bioRxiv · May 14, 2024Pharmacology & Toxicology