Trajectory analysis of hepatic stellate cell differentiation reveals metabolic regulation of cell commitment and fibrosis
R. A. Martinez Garcia de la Torre, J. Vallverdu, Z. Xu, S. Arino, B. Aguilar-Bravo, P. Ruiz Blazquez, M. Fernandez Fernandez, A. Navarro-Gascon, A. Blasco-Roset, P. Sanchez--Fernandez-de-Landa, J. Pera Garcia, D. Romero-Moya, P. Ayuso Garcia, C. Martinez Sanchez, L. Zanatto, , P. Sancho-Bru
This study maps the differentiation trajectory of iPSCs to hepatic stellate cells, identifying RORA as a key regulator of metabolic reprogramming and fibrosis.
bioRxiv · Feb 15, 2024Cell Biology