Z. Xu

A Conserved Geometric Code: Extracellular Matrix Curvature Directs Cell Migration Strategy via Nuclear Mechanosensing

The paper shows ECM curvature directs cell migration through nuclear mechanosensing, revealing a geometric code influencing migration strategy and metastasis.

Non-enzymatic ABHD6 interacts with Akt-FoxO1 axis to regulate selective hepatic insulin resistance

This study identifies a non-enzymatic role of ABHD6 in regulating selective hepatic insulin resistance and MASLD through interaction with the Akt-FoxO1 axis.

Cell division protein A (CdpA) organises and anchors the division ring at midcell in haloarchaea

This study identifies CdpA as a protein involved in organizing and anchoring the division ring in Haloferax volcanii, showing its role in stabilizing FtsZ proteins during cell division.

MDRepo - an open environment for data warehousing and knowledge discovery from molecular dynamics simulations

MDRepo provides an open repository for storing and analyzing molecular dynamics simulations to support drug discovery and structural biology research.

Temporal-spatially metabolic reprogramming rewires the H3K27ac landscape to enable the initiation of liver regeneration

This study identifies metabolic reprogramming and its impact on the H3K27ac epigenetic landscape during liver regeneration.

Interspecies interaction reshapes the fitness landscape of evolved genotypes

This study investigates how interspecies interactions shape genetic and phenotypic diversity in a two-species microbial consortium over evolutionary time.

CREEPING STEM1 Regulates Directional Auxin Transport for Lodging Resistance in Soybean

This study identifies the CS1 gene in soybean, which regulates directional auxin transport and enhances lodging resistance, improving yield under high planting density.

Os-circANK negatively regulates resistance to bacterial blight in rice via Osa-miR398b/OsCSD1/OsCSD2 pathways

The paper identifies Os-circANK as a circRNA that suppresses rice resistance to bacterial blight by sponging Osa-miR398b and modulating OsCSD1/OsCSD2 expression.

Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

This study identifies exosomal hemoglobin transfer from non-neuronal cells to neurons under hypoxia as a mechanism to maintain mitochondrial homeostasis and protect against neurological injury.

Bridging the Gap: biofilm-mediated establishment of Bacillus velezensis on Trichoderma guizhouense mycelia

This study investigates bacterial-fungal interactions between Bacillus velezensis and Trichoderma guizhouense, showing biofilm-mediated colonization and gene expression changes that reveal complex dynamics in soil microbiota.

c-di-GMP modulates ribosome assembly by inhibiting rRNA methylation

This study shows c-di-GMP inhibits rRNA methylation by binding to RlmI, modulates ribosome assembly, and promotes antibiotic tolerance in E. coli.

Dynamic Modeling of Antibody Repertoire Reshaping in Response to Viral Infections

This study uses mathematical modeling to show that viral infections reshape the antibody repertoire through the proliferation of high-affinity antibody pools and contraction of low-affinity pools, with self-antigens maintaining antibody persistence.

An orphan viral genome with controversial evolutionary status sheds light on a distinct lineage of flavi-like virus infecting plants

This study resolves the taxonomic controversy of SRAV, a plant-infecting flavi-like virus, by showing it belongs to the Flaviviridae family and triggers host RNAi responses.

Development of a humanized anti-FABP4 monoclonal antibody for treatment of breast cancer

This paper develops humanized anti-FABP4 monoclonal antibodies that inhibit breast cancer tumor growth and metastasis by targeting FABP4's role in lipid metabolism.

Single cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization.

The paper analyzes bone metastases from six cancer types using single-cell RNA-seq to identify three immune archetypes and their mechanisms of bone colonization.

Unbiased metastatic niche-labeling identifies estrogen receptor-positive macrophages as a barrier of T cell infiltration during bone colonization

Expanding the genome information on Bacillales for biosynthetic gene cluster discovery

This study presents 121 new Bacillales genomes, identifies 1,176 biosynthetic gene clusters, and provides open-access data to enhance research on secondary metabolite production.

Nanocluster-antibody-drug conjugates (NADC) as an intravesical precision theranostic agent for interstitial cystitis

This paper develops a nanocluster-antibody-drug conjugate (NADC) for interstitial cystitis, showing it targets NGF-overexpressing bladder lesions and reduces inflammation in rat models.

Positive Selection on Rare Variants Underlying the Cold Adaptation of Wild Boar

This study identifies rare variants under positive selection in wild boar linked to cold adaptation, showing convergent molecular evolution with humans.

Onco-Circuit Addiction and Onco-Nutrient mTORC1 Signaling Vulnerability in a Model of Aggressive T Cell Malignancy

The paper shows that mTORC1 signaling hypersensitivity to leucine drives an onco-circuit in T cell malignancy, and a low leucine diet is therapeutic without impairing T cell immunity.

Molecular basis for the activation of the Fatty Acid Kinase complex of Staphylococcus aureus

This study investigates the structure and function of the Fatty Acid Kinase complex in Staphylococcus aureus using modeling, biochemical, and cell-based approaches, revealing key residues and interactions essential for its activity.

Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy

This study reveals the conformational landscape of soluble α-klotho using cryo-EM, showing flexibility and multiple forms that support its FGFR-independent functions.

The TCRs of pathogenic Th17 cells in arthritogenic mice are shifted toward a Treg-like repertoire

The paper shows that ZAP-70 mutations in mice lead to a shift in T cell repertoires, with pathogenic Th17 cells resembling Tregs and contributing to autoimmune arthritis.

Study of Impacts of Two Types of Cellular Aging on the Yeast Bud Morphogenesis

This study analyzes two aging modes in yeast, showing spherical budding cells better control growth and size, and develops a model to test mechanisms of bud morphogenesis during aging.

Design and optimization of novel succinate dehydrogenase inhibitors against agricultural fungi based on Transformer model

This study uses a Transformer model to design novel succinate dehydrogenase inhibitors against agricultural fungi, resulting in potent antifungal compounds through virtual screening and optimization.

Highly efficient in vivo mutagenesis method based on the endonuclease and exonuclease activity of Bacillus alcalophilus RecJ (BaRecJ)

This paper introduces a novel mutagenesis method using BaRecJ's endonuclease and exonuclease activities, showing broader mutation spectra and improved trait-associated gene identification in E. coli and S. cerevisiae.

TLR9 activation in large wound induces tissue repair and hair follicle regeneration via gamma delta T cells

This study shows that TLR9 activation in wounds promotes tissue repair and hair follicle regeneration through gamma delta T cells by increasing AREG production and modulating keratinocyte fate.

Trajectory analysis of hepatic stellate cell differentiation reveals metabolic regulation of cell commitment and fibrosis

This study maps the differentiation trajectory of iPSCs to hepatic stellate cells, identifying RORA as a key regulator of metabolic reprogramming and fibrosis.

Mathematical Modelling Indicates Th-cell Targeted Antibody-Dependent Cellular Cytotoxic Is a Crucial Obstacle Hurdling HIV Vaccine Development

This paper uses mathematical modeling to show that ADCC targeting Th cells hinders HIV vaccine development by damaging immune responses and reducing vaccine effectiveness.

Modeling reveals the strength of weak interactions in stacked ring assembly

The paper develops a mathematical model of stacked trimer assembly, revealing that strong interaction affinities can lead to kinetic trapping, suggesting evolutionary pressure for weaker interactions in stacked ring structures.