GMMA can stabilize proteins across different functional constraints
N. Daffern, K. E. Johansson, Z. Baumer, N. Delbert-Robertson, J. Woojuh, M. A. Bedewitz, Z. Davis, I. Wheeldon, S. Cutler, K. A. Lindorff-Larsen, T. A. Whitehead
The paper identifies 5 stabilizing mutations for PYR1 variants using GMMA that increase thermal stability without affecting functionality across different ligand-binding capabilities.
bioRxiv · Jan 30, 2024Biochemistry