J.-M. Arbona

DNA replication and polymer chain duplication reshape the genome in space and time

The paper develops a computational framework to model DNA replication dynamics and their impact on chromosome organization, showing replication-dependent loop extrusion and sister chromatid interactions in yeast.

Neural network and kinetic modelling of human genome replication reveal replication origin locations and strengths

The paper uses neural networks and kinetic modeling to infer replication origin locations and strengths from replication timing and direction data, revealing that origin efficiency is determined by both licensing and firing steps.

Organization of DNA replication origin firing in Xenopus egg extracts : the role of intra-S checkpoint

The paper models DNA replication origin firing in Xenopus egg extracts to show checkpoint regulation influences origin clustering dynamics.

Universal temporal rate of DNA replication origin firing: A balance between origin activation and passivation

The paper shows that the universal bell-shaped replication origin firing rate can be explained by diffusion of fork components and competition between firing time and DNA replication time.