Author

M. M. Tortora

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Approach:statistical model· 2 Approach:biophysical modeling· 1 Assay:DNA methylation· 1 Organism:Drosophila· 1 Assay:Hi-C· 1 Approach:mechanistic / dynamical model· 1 Organism:yeast· 1

Frequent Co-Authors

D. Jost· 3 shared C. Vaillant· 2 shared A. Z. Abdulla· 1 shared D. D'Asaro· 1 shared G. Karpen· 1 shared J.-M. Arbona· 1 shared L. Brennan· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 11 mutual co-author links

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3 shared papersBiophysics

D. Jost

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Author profile →

3 papers

Recent·Most cited

DNA replication and polymer chain duplication reshape the genome in space and time

D. D'Asaro, M. M. Tortora, C. Vaillant, J.-M. Arbona, D. Jost

The paper develops a computational framework to model DNA replication dynamics and their impact on chromosome organization, showing replication-dependent loop extrusion and sister chromatid interactions in yeast.

bioRxiv · Mar 12, 2024Biophysics

Topological constraints and finite-size effects in quantitative polymer models of chromatin organization

A. Z. Abdulla, M. M. Tortora, C. Vaillant, D. Jost

This paper investigates the minimal chromosome length needed for accurate polymer simulations of chromatin organization, showing how topological constraints and finite-size effects influence sub-chromosomal structure and dynamics.

bioRxiv · Jun 16, 2023Biophysics

HP1-driven phase separation recapitulates the thermodynamics and kinetics of heterochromatin condensate formation

M. M. Tortora, L. Brennan, G. Karpen, D. Jost

This paper investigates how HP1-driven phase separation forms PCH condensates in vivo, showing that HP1-chromatin interactions and genomic H3K9me2/3 distribution govern their thermodynamics and kinetics.

bioRxiv · Jul 11, 2022 · PreprintBiophysics