Author

Jacob Bandell

Northeastern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:DNA methylation· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Konstantin KhrapkoiD· 2 shared Konstantin Yu. PopadiniD· 2 shared Melissa FrancoiD· 2 shared Auden Cote‐L’HeureuxiD· 1 shared Benjamin Vyshedskiy· 1 shared Daniil Mirzoyan· 1 shared Dori C. WoodsiD· 1 shared Dori Woods· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersGenetics

Konstantin KhrapkoORCID

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2 papers

Recent·Most cited

Positive germline selection of mtDNA: evidence from the oocyte.

Melissa Franco, Zoë Fleischmann, Sofia Annis, Auden Cote‐L’Heureux, Dylan Aidlen, Mark Khrapko, Benjamin Vyshedskiy, Mary K. Hartigan, Daniil Mirzoyan, Jacob Bandell, Konstantin Yu. Popadin, Dori C. Woods, Jonathan L. Tilly, Konstantin Khrapko

The paper analyzes mtDNA mutation dynamics in human oocytes and finds evidence of positive selection for noncoding and coding mutations, suggesting a shift from positive to purifying selection upon inheritance.

bioRxiv · Jul 14, 2026 · PreprintGenetics

Are mitochondrial DNA mutations under purifying selection in somatic tissues?

Melissa Franco, Jacob Bandell, Konstantin Yu. Popadin, Dori Woods, Konstantin Khrapko

The paper reanalyzes mtDNA mutation data to determine if somatic mutations are under purifying selection, finding that apparent selection signals are due to germline mutations and most somatic mutations are neutral.

bioRxiv · Oct 26, 2025 · PreprintGenetics