Dylan Aidlen

Positive germline selection of mtDNA: evidence from the oocyte.

The paper analyzes mtDNA mutation dynamics in human oocytes and finds evidence of positive selection for noncoding and coding mutations, suggesting a shift from positive to purifying selection upon inheritance.

Coupling high-throughput protease enzymology with viral replication reveals biochemical constraints of viral fitness

The paper links protease sequence variation to biochemical parameters and viral fitness using high-throughput enzymology and replication assays.

Processing and Analyzing High-Throughput Microfluidic Enzymology Data: A Practical Guide To Rate Fitting and Quality Control

The paper provides a guide for analyzing high-throughput microfluidic enzymology data, focusing on quality control and rate fitting using Michaelis-Menten kinetics.

Reanalysis of mtDNA mutations of human primordial germ cells (PGCs) reveals NUMT contamination and suggests that selection in PGCs may be positive

The paper reanalyzes mtDNA mutation data from human primordial germ cells, identifies NUMT contamination, and suggests that selection in PGCs may be positive rather than negative.

Dynamics of the most common pathogenic mtDNA variant m.3243A>G demonstrate frequency-dependency in blood and positive selection in the germline.

This paper shows that the m.3243A>G mtDNA mutation levels in blood change in a bi-phasic way with age, requiring an age correction dependent on mutation level, and finds evidence for positive germline selection of this mutation.