Molecular cloning of a novel, nervous system-specific RGS6 isoform lacking canonical G protein regulatory effects and with dominant negative actions
Katelin Dannen, Jianqi Yang, Jacob Bernholtz, Alexander G P Glebov-McCloud, Stefan Strack, John G. Koland, R Fisher, Adele Stewart
The paper identifies a novel RGS6 isoform, RGS6B, which lacks canonical G protein regulatory effects but exhibits dominant negative actions and stabilizes RGS6 binding partners.
bioRxiv · May 12, 2026 · PreprintNeuroscience