Microenvironmental variables must influence intrinsic phenotypic parameters of cancer stem cells to affect tumourigenicity
Jacob Scott, Anita Hjelmeland, Prakash Chinnaiyan, Alexander R A Anderson, David Basanta
The paper develops a computational model to study how microenvironmental factors influence cancer stem cell phenotypes and tumour growth, finding that microenvironmental variables have limited impact and that intrinsic parameters are more critical.
bioRxiv · Nov 7, 2013Cancer Biology