Low-Dose Interleukin-2 Resolves Stress-Induced Chronic Sensitization Independent of Opioid Receptor Signaling
Róli Rodrigues Simões, Scheila Kraus, Jintao Zhang, Leandro Flores do Nascimento, Dilip K. Tosh, Jacqueline Unsinger, Richard S. Hotchkiss, Tao Che, Kenneth A. Jacobson, Yuqing Q. Cao
This study identifies multiple pathways suppressing stress-induced chronic pain and shows low-dose IL-2 effectively resolves sensitization without relying on opioid or GABA signaling.
bioRxiv · Sep 5, 2026 · PreprintNeuroscience